Title: Pivotal trial of MRI-guided transurethral ultrasound ablation (TULSA) of localized prostate cancer: 4-year follow-up
Pavlovich et al, AUA 2023 Annual Meeting (abstract MP73-05), The Journal of Urology (2023)
Clinical Research
Profound Medical is committed to research, innovation, improving procedure efficiency and saving lives. We are dedicated to changing the standard of care through quality clinical evidence, working in close partnership with clinicians, physicians, hospitals, and professional associations.
Featured Presentations
Title: Prostate Cancer Ablation Using MRI-Guided Transurethral Ultrasound (TULSA-PRO): How I Do it?
Ram A. Pathak, MD
Klotz et al, Focal Therapy Society Annual Meeting 2023
Featured Publications
Clinical Publications
Primary Evidence of Safety & Efficacy: TACT Pivotal Study (n=115)
Title: Pivotal trial of MRI-guided transurethral ultrasound ablation (TULSA) of localized prostate cancer: 4-year follow-up
Muschter et al, AUA 2023 Annual Meeting (abstract MP73-09) ,The Journal of Urology (2023)
Title: Magnetic Resonance Imaging-Guided Transurethral Ultrasound Ablation of Prostate Cancer
Klotz et al, The Journal of Urology (2021)
Title: Single-center evaluation of treatment success using two different protocols for MRI-guided transurethral ultrasound ablation of localized prostate cancer
Hatiboglu et al, Frontiers in Oncology (2021)
Title: PIVOTAL TRIAL OF MRI-GUIDED TRANSURETHRAL ULTRASOUND ABLATION IN MEN WITH LOCALIZED PROSTATE CANCER: THREE-YEAR FOLLOW-UP
Klotz et al, The Journal of Urology (2021)
Title: MR Imaging-Guided Transurethral Ultrasound Ablation of Localized Prostate Cancer: Preliminary Experience from a Single Center in a Prospective, Multi-Center, Single-Arm Clinical Trial
Sundaram et al, Journal of Vascular and Interventional Radiology (2020)
Confirmation of Safety & Efficacy in Routine Clinical Practice
Title: A retrospective clinical service evaluation of lesion-targeted MRI-guided transurethral ultrasound ablation (TULSA) for the treatment of localized prostate cancer
Muschter et al, AUA 2023 Annual Meeting (abstract MP73-09) ,The Journal of Urology (2023)
Title: Initial experience of transurethral ultrasound ablation of the prostate in Asia”, BJUI Compass
Miura et al, BJUI Compass (2022)
Title: Early Single-center Experience with TULSA-PRO (outside of Clinical Trials): Initial United States Experience
Kasraeian et al, WCET 2022 Annual Meeting (abstract MP20-14), Journal of Endourology (2022)
Title: Customized prostate ablation using MRI-guided transurethral ultrasound ablation (TULSA): initial experience at a private radiology practice
Busch et al, SIR 2022 Annual Scientific Meeting (Abstract No. 112), Journal of Vascular and Interventional Radiology (2022)
Title: Single center retrospective analysis of fifty-two prostate cancer patients with customized MR-guided transurethral ultrasound ablation (TULSA)
Lumiani et al, Urologic Oncology (2021)
Durability of Outcomes and Feasibility of Salvage Treatment: Phase I Safety & Precision Study (n=30)
Title: Salvage Magnetic Resonance Imaging-guided Transurethral Ultrasound Ablation for Localized Radiorecurrent Prostate Cancer
Anttinen et al, European Urology Open Science (2024)
Title: Durability of Functional Outcomes After MRI-Guided Transurethral Ultrasound Ablation of the Prostate
Hatiboglu et al, JU Open Plus (2023)
Title: Salvage open radical prostatectomy for recurrent prostate cancer following MRI-guided transurethral ultrasound ablation (TULSA) of the prostate: feasibility and efficacy
Nair et al, Scandinavian Journal of Urology (2020)
Title: Twelve-month prostate volume reduction after MRI-guided transurethral ultrasound ablation of the prostate
Bonekamp et al, European Radiology (2018)
Demonstrating Feasibility in other Prostate Disease States
Title: Magnetic resonance imaging-guided transurethral ultrasound ablation for benign prostatic obstruction: 1-year clinical outcomes of a phase II study
Viitala et al, British Journal of Urology International (2025)
Title: Transurethral ultrasound ablation (TULSA) for benign prostatic obstruction: 12 months clinical outcomes
Anttinen et al, AUA 2023 Annual Meeting (abstract MP76-10), The Journal of Urology (2023)
Title: MRI-guided transurethral ultrasound ablation for BPH: 12-month clinical outcomes of a phase I study
Viitala et al, British Journal of Urology International (2021)
Title: Salvage transurethral ultrasound ablation (TULSA) for localized radio-recurrent prostate cancer: 12-month safety and oncological outcomes
Anttinen et al, EAU 2023 Annual Congress (abstract A0965), The Journal of Urology (2023)
Title: Salvage MRI-guided TULSA for localized radio-recurrent prostate cancer: 12-month functional and oncological results
Anttinen et al, European Urology Open Science (2020)
Title: Palliative MRI-guided transurethral ultrasound ablation for symptomatic locally advanced prostate cancer
Anttinen et al, Scandinavian Journal of Urology (2020)
Title: 12-month clinical outcomes of MRI-guided transurethral ultrasound ablation for localized prostate cancer
Yli-Pietilä et al, EAU 2023 Annual Congress (abstract A0996), European Urology (2023)
Title: Comparison of postoperative complications between focal ablation and radical prostatectomy for intermediate-risk prostate cancer: the FARP randomized control trial
Baco et al, AUA 2023 Annual Meeting (abstract MP73-15), The Journal of Urology (2023)
Title: Optimal strategies for managing prostate-specific antigen recurrence after primary radiotherapy in prostate cancer: The Finnish Perspective
Seikkula et al, European Urology Focus (2023)
Review Articles and Commentaries
Title: Transurethral Ultrasound Ablation as a Promising Focal Therapy Option for Prostate Cancer
Chin et al, AUANews (2023)
Title: Evolving imaging methods of prostate cancer and the emergence of magnetic resonance imaging guided ablation techniques
Anttinen et al, Frontiers in Oncology (2022)
Title: Real-Time MRI-Guided Prostate Interventions
Masoom et al, Cancers (Basel) (2022)
Title: Magnetic Resonance Imaging-Guided Transurethral Ultrasound Ablation of Prostate Cancer: A Systematic Review
Dora et al, Journal of Endourology (2022)
Title: The role for MRI-guided transurethral ultrasound ablation in the continuum of prostate cancer care
Busch et al, The British Journal of Radiology (2022)
Title: MR imaging in real time guiding of therapies in prostate cancer
Wimper et al, Life (2022)
Title: Minimally invasive magnetic resonance image-guided prostate interventions
Van Luijtelaar et al, British Journal of Radiology (2021)
Title: MR-guided high-intensity directional ultrasound ablation of prostate cancer
Galgano et al, Current Urology Report (2021)
Title: Does MRI-guided TULSA provide a targeted approach to ablation?
Arcot et al, Nat Rev Urol (2020)
Title: Therapeutic ultrasound and prostate cancer
Seikkula et al, European Urology Focus (2023)Sundaram et al, Semin Intervent Radiol (2017)
Title: Evolution of non-perfused volume after transurethral ultrasound ablation of prostate: A retrospective 12-month analysis
Mäkelä et al, European Journal of Radiology Open (2023)
Title: Fiducial markers and their impact on ablation outcome for patients treated with MR- guided transurethral ablation (TULSA): a retrospective technical analysis
Wright et al, International Journal of Hyperthermia (2021)
Title: Acute and subacute prostate MRI findings after MRI-guided transurethral ultrasound ablation of prostate cancer
Makela et al, Acta Radiologica (2020)
Title: Histopathological evaluation of prostate specimens after thermal ablation may be confounded by the presence of thermally-fixed cells
Anttinen et al, International Journal of Hyperthermia (2019)
Title: Feasibility of MRI-guided transurethral ultrasound for lesion-targeted ablation of prostate cancer
Anttinen et al, Scandinavian Journal of Urology (2019)
Title: Evaluation of focal ablation of MRI-defined prostate cancer using MRI-controlled transurethral ultrasound therapy with prostatectomy as the reference standard
Ramsay et al, Journal of Urology 197: 255-261 (2017)
Title: MR Imaging-controlled transurethral ultrasound therapy for conformal treatment of prostate tissue: Initial feasibility in humans
Chopra et al, Radiology 265(1): 303-13 (2012)
Early Development
Title: Magnetic resonance image guided transurethral ultrasound prostate ablation: A preclinical safety and feasibility study with 28-day follow-up
Burtnyk et al, The Journal of Urology 193: 1669-1675 (2015)
Title: Cavernosal nerve functionality evaluation after magnetic resonance imaging-guided transurethral ultrasound treatment of the prostate
Sammet et al, World Journal of Radiology 7(12): 521-530 (2015)
Title: MRI-guided transurethral ultrasound therapy of the prostate gland using real-time thermal mapping: initial studies
Siddiqui et al, Urology 76(6): 1506-11 (2010)
Title: MRI-controlled transurethral therapy for localized prostate cancer
Chopra et al, International Journal of Hyperthermia 26(8): 804-21 (2010)
Title: Analysis of the spatial and temporal accuracy of heating in the prostate gland using transurethral ultrasound therapy and active MR temperature feedback
Chopra et al, Physics in Medicine and Biology 54: 2615-33 (2009)
Title: MRI-compatible transurethral ultrasound system for the treatment of localized prostate cancer using rotational control
Chopra et al, Medical Physics 35: 1346-57 (2008)
Title: Prostate tissue analysis immediately following magnetic resonance imaging guided transurethral ultrasound thermal therapy
Boyes et al, The Journal of Urology 178: 1080-5 (2007)
Title: Conformal thermal therapy using planar ultrasound transducers and adaptive closed-loop MR temperature control: demonstration in gel phantoms and ex vivo tissues
Tang K et al, Physics in Medicine and Biology, 52: 2905-19 (2007)
Title: Transurethral ultrasound therapy of the prostate in the presence of calcifications: A simulation study
Suomi et al, Medical Physics (2018)
Title: Investigation of power and frequency for 3D conformal MRI-controlled transurethral ultrasound therapy with a dual frequency multi-element transducer
N’Djin et al, Int J Hyperthermia 28(1): 87-104 (2012)
Title: Coagulation of human prostate volumes with MRI-controlled transurethral ultrasound therapy: results in gel phantoms
N’Djin et al, Medical Physics 39(7): 4524-36 (2012)
Title: Simulation study on the heating of the surrounding anatomy during transurethral ultrasound prostate therapy: A 3D theoretical analysis of patient safety
Burtnyk et al, Medical Physics 37(6): 2862-75 (2010)
Title: 3D Conformal MRI-controlled transurethral ultrasound prostate therapy: validation of numerical simulations and demonstration in tissue-mimicking gel phantoms
Burtnyk et al, Physics in Medicine and Biology 55(22):6817-39 (2010)
Title: Quantitative analysis of 3D conformal MRI-guided transurethral ultrasound therapy of the prostate: theoretical simulations
Burtnyk et al, International Journal of Hyperthermia 25(2): 116-31 (2009)
Title: Analysis of factors important for transurethral ultrasound prostate heating using MR temperature feedback
Chopra et al, Physics in Medicine and Biology 51: 827-44 (2006)
Title: Method for MRI-guided conformal thermal therapy of prostate with planar transurethral ultrasound heating applicators
Chopra et al, Physics in Medicine and Biology 50: 4957-75 (2005)
In the United States, TULSA-PRO has 510(k) regulatory clearance and is indicated for the ablation of prostate tissue, on the basis of clinical trials in men with localized prostate cancer where whole-gland ablation of benign and malignant prostate tissue demonstrated significant PSA reduction, prostate volume reduction, and follow-up biopsies that were negative for residual prostate cancer. As with other ablation devices, surgical robots, and radiotherapy machines, TULSA-PRO is a tool for the removal or destruction of prostate tissue; the effectiveness of TULSA-PRO or other devices in treating prostate cancer has not been established.
CAUTION: Products shown may not be approved for sale in all jurisdictions. Rx only device.
Contact us at [email protected] for more information regarding the regulatory status of the device.
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